Nature Reviews Genetics Contents June 2013 Volume 14 Number 6 pp 367-440

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TABLE OF CONTENTS
June 2013 Volume 14 Number 6		Advertisement
Impact Factor 38.075 *	In this issue Research Highlights Ethics Watch Progress Reviews Also this month Article series: Translational genetics Genome-wide association studies  Featured article: Molecular genetic testing and the future of clinical genomics Sara Huston Katsanis & Nicholas Katsanis	GRANT - Staying on the cutting edge is all about collaboration. That's why Expression Analysis & Illumina have combined forces to help fuel your research. FULLY-FUNDED GRANT - Integrated Biology Approach to Genetic Research. Apply online today or call 919-405-2248 * 866-293-6094
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RESEARCH HIGHLIGHTS Top Gene expression: Super enhancers p367 | doi:10.1038/nrg3496 PDF Population genomics: Noah's Ark arrives p368 | doi:10.1038/nrg3499 PDF Genomics: New zebrafish genome resources p368 | doi:10.1038/nrg3500 PDF Population genetics: Mobile elements across human populations p370 | doi:10.1038/nrg3497 PDF Epigenetics: Legionella makes its mark on histones p370 | doi:10.1038/nrg3498 PDF AN INTERVIEW WITH... Eric Olson p371 | doi:10.1038/nrg3501 The 2013 March of Dimes Prize in Developmental Biology has been awarded to Eric Olson of the University of Texas Southwestern for his pioneering research on the molecular mechanisms of heart and other muscle development. The prize recognizes researchers whose work has contributed to our understanding of the science that underlies birth defects. Hannah Stower talked to Eric Olson about the impact his achievements have had on human health. PDF IN BRIEF Stem cells: Nuclear departure controls pluripotency exit | Epigenetics: BPA and imprinting disruption | Non-coding RNA: R-loop stability controls expression | Gene regulation: Determining global and specific regulation | Epigenetics: Genome-wide views of methylation readers | Transcriptomics: Isoform diversity revealed | Disease genetics: Improving GWASs with secondary phenotypes | Development: Testing the threshold-dependent model PDF Genetics JOBS of the week Postdoctoral Scholar - Microbial Pathogenesis University of California, Irvine Scientist in Neurodevelopmental Diseases F. Hoffmann-La Roche AG Postdoctoral associate Yale Medical School Scientist Wheat Crop Genetics (m / f) Bayer CropScience SA NV Postdoctoral fellow position in the area of Computational Cancer Genomics University of Cologne, Department of Translational Genomics More Science jobs from Genetics EVENT Mouse Molecular Genetics 18.09.13 Cambridge, UK More science events from
ETHICS WATCH		Top
Rare diseases and now rare data? Deborah Mascalzoni, Bartha Maria Knoppers, Ségolène Aymé, Matteo Macilotti, Hugh Dawkins, Simon Woods & Mats G. Hansson p372 | doi:10.1038/nrg3494 Rare disease research is threatened by proposed changes to European privacy laws. Full Text | PDF
PROGRESS		Top
Article series: Translational genetics Therapy for Duchenne muscular dystrophy: renewed optimism from genetic approaches Rebecca J. Fairclough, Matthew J. Wood & Kay E. Davies p373 | doi:10.1038/nrg3460 Several promising genetic approaches are being investigated for the treatment of Duchenne muscular dystrophy, including traditional gene therapy, stop codon read-through, exon skipping and increased expression of a compensatory gene. The lessons learned should also be valuable for other disorders. Abstract | Full Text | PDF
REVIEWS		Top
Article series: Genome-wide association studies Meta-analysis methods for genome-wide association studies and beyond Evangelos Evangelou & John P. A. Ioannidis p379 | doi:10.1038/nrg3472 The authors review statistical methods for meta-analysis of genome-wide association studies (GWASs) and extensions of these methods to complex data. They discuss how low-frequency variants can be incorporated into meta-analyses as next-generation sequencing data become more commonly used in GWASs. Abstract | Full Text | PDF
Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data Job Dekker, Marc A. Marti-Renom & Leonid A. Mirny p390 | doi:10.1038/nrg3454 The three-dimensional organization of genomes can now be explored at increased resolution using approaches based on 3C technology. This Review discusses how these chromatin interaction data sets can be interpreted using statistical approaches and computational modelling, and considers the levels of organization that are revealed. Abstract | Full Text | PDF
Understanding the origin of species with genome-scale data: modelling gene flow Vitor Sousa & Jody Hey p404 | doi:10.1038/nrg3446 Genome-wide data hold the key to answering long-standing questions about the mechanisms of speciation, including the role of gene flow. Here, the authors discuss recently developed methods to analyse genome-wide data and consider emerging results from their recent application. Abstract | Full Text | PDF
Article series: Translational genetics Molecular genetic testing and the future of clinical genomics Sara Huston Katsanis & Nicholas Katsanis p415 | doi:10.1038/nrg3493 The authors review current technologies for clinical genetic testing. Moves are being made towards whole-genome and whole-exome sequencing in the clinic, although other technologies will continue to be of value. Abstract | Full Text | PDF
Mechanisms and models of somatic cell reprogramming Yosef Buganim, Dina A. Faddah & Rudolf Jaenisch p427 | doi:10.1038/nrg3473 Our understanding of the molecular steps that occur during reprogramming somatic cells to induced pluripotent stem cells has recently been improved through analyses of cell populations and single cells. Here the authors consider the phases of reprogramming, models for describing the process and the roles of reprogramming factors. Abstract | Full Text | PDF
Erratum: From neural development to cognition: unexpected roles for chromatin Jehnna L. Ronan, Wei Wu & Gerald R. Crabtree p440 | doi:10.1038/nrg3508 Full Text | PDF
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