Nature Reviews Molecular Cell Biology contents January 2012 Volume 13 Number 1 pp1-60

TABLE OF CONTENTS
January 2012 Volume 13 Number 1		Advertisement
Impact Factor 38.65 *	In this issue Research Highlights Progress Reviews Perspectives Also this month Article series: Post-translational modifications  Featured article: Regulating the regulator: post-translational modification of RAS Ian M. Ahearn, Kevin Haigis, Dafna Bar-Sagi & Mark R. Philips	Is your washer limiting your results? Benefit from Tecan's new HydroSpeed™ expert plate washer, offering: • Extra gentle Cell Protection™ • wash settings • Dual magnets for efficient • magnetic bead processing • Anti-Clogging™ function for • reliable ELISA washing Learn More
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
Nature Reviews Genetics ANIMATION ON RNA INTERFERENCE Nature Reviews Genetics, in association with Arkitek Studios, has brought RNAi to life in this vivid, audio-visual journey into the cell. See RNAi in action by viewing the animation for FREE at: www.nature.com/nrg/multimedia/rnai Produced with support from Thermo Scientific
RESEARCH HIGHLIGHTS Top Gene expression: An ncRNA relocation package p1 | doi:10.1038/nrm3258 ncRNAs regulate gene localization between distinct nuclear subcompartments. PDF Cell migration: H2O2 sensing: the missing 'Lynk' p2 | doi:10.1038/nrm3250 Lyn senses H2O2 at wound sites and mediates neutrophil migration. PDF Cytoskeleton: A stabilizing influence for K-fibres p2 | doi:10.1038/nrm3256 MCRS1 stabilizes K-fibres and spindle assembly in a RAN·GTP-dependent manner. PDF Nucleoskeleton: Uncovering roles for lamin B p3 | doi:10.1038/nrm3257 Two studies reveal roles for B-type lamins in organogenesis and cell proliferation. PDF Organelle dynamics: Stopping mitochondria in their tracks p4 | doi:10.1038/nrm3251 PINK1 phosphorylates MIRO; parkin then degrades MIRO to halt mitochondrial movement. PDF Stem cells: Stem cells follow the clock p4 | doi:10.1038/nrm3253 Epidermal stem cell activity is directly regulated by core clock proteins. PDF Cell signalling: Crystallizing WNT signalling p4 | doi:10.1038/nrm3260 Structural insight into the DKK1-mediated inhibition of WNT signalling. PDF JOURNAL CLUB Is chromatin helical? p6 | doi:10.1038/nrm3247 Discusses recent papers on the topography of the interphase chromatin fibre. PDF Microscopy: Easing access to the nanoscale p6 | doi:10.1038/nrm3259 A new method for high-resolution imaging using a standard wide-field microscope. PDF IN BRIEF Cell migration: IAPs targeting RAC1 | Cell cycle: Conserved role for RAB5 in mitosis | Plant cell biology: From chloroplast to nucleus PDF Molecular Cell Biology JOBS of the week Biophysics / Physical Chemistry - Nano and Microscale Mechanics of Polysaccharide-Rich Cellular Coats CIC Biomagune Senior Scientist in Bioprocess Department GenScript USA Inc. Postdoc on Genetic Regulation of Neural Stem Cells UT Southwestern Medical Center at Dallas Postdoctoral Fellow Weill Cornell Medical College, Cornell University Postdoctoral Fellowship Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) More Science jobs from Molecular Cell Biology EVENT Protein-RNA Interactions in Biology and Disease (C1) 04.-09.03.12 US More science events from
Erratum: Plant cell biology: Sensing oxygen Kim Baumann p5 | doi:10.1038/nrm3252 Full Text | PDF
PROGRESS		Top
Canonical and non-canonical autophagy: variations on a common theme of self-eating? Patrice Codogno, Maryam Mehrpour & Tassula Proikas-Cezanne p7 | doi:10.1038/nrm3249 The autophagosome, the central organelle in macroautophagy, is constructed from a membrane template called the phagophore, to which autophagy-related (ATG) proteins are hierarchically recruited. Recent findings suggest that non-canonical autophagy may also occur in the absence of these key autophagy proteins. Abstract | Full Text | PDF
Corrigendum: Dynamic niches in the origination and differentiation of haematopoietic stem cells Leo D. Wang & Amy J. Wagers p12 | doi:10.1038/nrm3245 Full Text | PDF
REVIEWS		Top
Walking to work: roles for class V myosins as cargo transporters John A. Hammer, III & James R. Sellers p13 | doi:10.1038/nrm3248 Cells use molecular motors to position and segregate organelles. Recent studies show that class V myosins function as actin-based cargo transporters in yeast, moving the vacuole, peroxisomes and secretory vesicles. There is also increasing evidence in vertebrate cells that class V myosins can serve as short-range, point-to-point organelle transporters rather than just tethering organelles to actin. Abstract | Full Text | PDF | Supplementary information
Building strong bones: molecular regulation of the osteoblast lineage Fanxin Long p27 | doi:10.1038/nrm3254 Bone homeostasis depends on the opposing activities of osteoblasts (which form bone) and osteoclasts (which destroy bone). Recent studies have revealed the transcription factors (for example, RUNX2 and osterix) and developmental signalling pathways (including WNT and Notch signalling) that regulate the differentiation and function of osteoblasts. Abstract | Full Text | PDF
Article series: Post-translational modifications Regulating the regulator: post-translational modification of RAS Ian M. Ahearn, Kevin Haigis, Dafna Bar-Sagi & Mark R. Philips p39 | doi:10.1038/nrm3255 RAS proteins are monomeric GTPases that act as binary molecular switches to regulate a wide range of cellular processes. Their trafficking and activity are regulated by constitutive post-translational modifications (PTMs), including farnesylation, methylation and palmitoylation, as well as conditional PTMs, such as phosphorylation, peptidyl-proly isomerization, ubiquitylation, nitrosylation, ADP ribosylation and glucosylation. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles Radek Dobrowolski & Edward M. De Robertis p53 | doi:10.1038/nrm3244 Although the multivesicular body (MVB) is classically defined as an intermediate that delivers material for lysosomal degradation, its role in the sequestration of glycogen synthase kinase 3 during WNT signalling has revealed a positive influence of this organelle in signalling control. This Opinion article proposes that this function of MVBs as a signalling organelle is physiologically relevant during development and may be common to diverse signalling pathways. Abstract | Full Text | PDF
Advertisement
Nature Outlook: Multiple Myeloma Although a cure remains a long way off, study of multiple myeloma is yielding insights into bone biology, the role of the tumour microenvironment and the origins of a whole range of different cancers. Access the Outlook free online for six months and request your free copy. Produced with support from: Onyx Pharmaceuticals, Inc.
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*Journal Citation Reports, Thomson, 2010

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.