Molecular Systems Biology - New articles published 20 December 2011

Latest Articles 20 December 2011   Featured Article Research Articles Perspective   Web feeds About Open access Advertisement FROM 'OMICS' TO SINGLE MOLECULES Download & Discover our new podcast, featuring interviews with Dr Peer Bork, Prof Peter Sorger and Dr Jan Ellenberg. A POWERFUL PLACE TO BE Watch our video interview of Nobel Prize winner Eric Wieschaus.     Featured Article Queueing up for enzymatic processing: correlated signaling through coupled degradation Overloaded enzymatic processes are shown to create indirect coupling between upstream components in cellular networks. This has important implications for the design of synthetic biology devices and for our understanding of currently inexplicable links within endogenous biological systems. Natalie A Cookson, William H Mather, Tal Danino, Octavio Mondragón-Palomino, Ruth J Williams, Lev S Tsimring & Jeff Hasty Molecular Systems Biology 7:561; doi:10.1038/msb.2011.94; published 20 December 2011 Synopsis | Full Text | PDF | Supp. Inf. | Review Process Research Articles Programmed fluctuations in sense/antisense transcript ratios drive sexual differentiation in S. pombe Strand-specific RNA sequencing of S. pombe reveals a highly structured programme of ncRNA expression at over 600 loci. Functional investigations show that this extensive ncRNA landscape controls the complex programme of sexual differentiation in S. pombe. Danny A Bitton, Agnes Grallert, Paul J Scutt, Tim Yates, Yaoyong Li, James R Bradford, Yvonne Hey, Stuart D Pepper, Iain M Hagan & Crispin J Miller Molecular Systems Biology 7:559; doi:10.1038/msb.2011.90; published 20 December 2011 Synopsis | Full Text | PDF | Supp. Inf. | Review Process Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation Inflammatory gene activation must be rigorously controlled to ensure a rapid, but transient, response. In this work, a regulatory circuit is revealed that governs the destabilization of inflammatory mRNAs and plays an essential role in re-establishing immune homeostasis after inflammatory stimulus. Franz Kratochvill, Christian Machacek, Claus Vogl, Florian Ebner, Vitaly Sedlyarov, Andreas R Gruber, Harald Hartweger, Raimund Vielnascher, Marina Karaghiosoff, Thomas Rülicke, Mathias Müller, Ivo Hofacker, Roland Lang & Pavel Kovarik Molecular Systems Biology 7:560; doi:10.1038/msb.2011.93; published 20 December 2011 Synopsis | Full Text | PDF | Supp. Inf. | Review Process Environmental and genetic perturbations reveal different networks of metabolic regulation Measurement of metabolic and physiological parameters in replicated crosses of Drosophila melanogaster inbred lines reveals that environmental and genetic perturbations uncover substantially different networks of metabolic regulation. Anthony J Greenberg, Sean R Hackett, Lawrence G Harshman & Andrew G Clark Molecular Systems Biology 7:563; doi:10.1038/msb.2011.96; published 20 December 2011 Synopsis | Full Text | PDF | Supp. Inf. | Review Process Perspective 5-Hydroxymethylcytosine: a new kid on the epigenetic block? Filomena Matarese, Enrique Carrillo-de Santa Pau & Hendrik G Stunnenberg Molecular Systems Biology 7:562; doi:10.1038/msb.2011.95; published 20 December 2011 Full Text | PDF

Advertisement

Gordon Research Conferences is pleased to announce the following meetings for 2012: Biomolecular Interactions & Methods January 15–20, 2012 A GRS* will be held before this meeting (Jan 14–15) Nox Family NADPH Oxidases June 3-8, 2012 A GRS* will be held before this meeting (Jun 2-3) *A GRS is a 2-day seminar for grad students & post-docs preceding an associated GRC. For more information, please visit http://www.grc.org

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2011 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.